Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat
نویسندگان
چکیده
منابع مشابه
Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes
It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...
متن کاملmetabolism and cytotoxic mechanisms of nitroglycerin in isolated rat hepatocytes
it has been proposed that organic nitrates such as glyceryl trinitrate (gtn), used in the treatment of cardiovascular diseases, act by producing nitric oxide (no). however, the biochemical pathway for no formation from gtn is not well understood. in the present study, we showed that nitrate formation from gtn, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione was de...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2016
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2016.01.005